Recently, controlled and sustained drug delivery has become the standard in modern Pharmaceutical design and an intensive research have been done in getting much better drug product effectiveness, reliability and safety. This interest has been increased by the advantages shown by in situ forming polymeric delivery systems such as ease of administration and reduced frequency of administration, improved patient compliance and comfort. Among oral dosage form, liquid dosage forms are more prone to low bioavailability because of their faster transit from the stomach. The sustained release of the drug from the oral liquid formulation can be obtained by liquid in situ gelling system. The formation of gels depends on factors like temperature change, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. The in situ gel forming polymeric formulations provide several advantages like sustained and prolonged action as compared to conventional drug delivery systems as well as produce patient compliance by reducing dosing frequency. From a view point of manufacturing, the production of such systems is less complex and thereby lowers the investment and manufacturing cost.
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